Synthesis of PDON-b-PEG-b-PDON block copolymers and drug delivery system thereof

Author(s):  
Hong Wang ◽  
Jian Hua Dong ◽  
Kun Yuan Qiu ◽  
Zhong Wei Gu
Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5147
Author(s):  
Wanting Hou ◽  
Ruiqi Liu ◽  
Siwei Bi ◽  
Qian He ◽  
Haibo Wang ◽  
...  

Due to a strong retardation effect of o-nitrobenzyl ester on polymerization, it is still a great challenge to prepare amphiphilic block copolymers for polymersomes with a o-nitrobenzyl ester-based hydrophobic block. Herein, we present one such solution to prepare amphiphilic block copolymers with pure poly (o-nitrobenzyl acrylate) (PNBA) as the hydrophobic block and poly (N,N’-dimethylacrylamide) (PDMA) as the hydrophilic block using bulk reversible addition-fragmentation chain transfer (RAFT) polymerization of o-nitrobenzyl acrylate using a PDMA macro-RAFT agent. The developed amphiphilic block copolymers have a suitable hydrophobic/hydrophilic ratio and can self-assemble into photoresponsive polymersomes for co-loading hydrophobic and hydrophilic cargos into hydrophobic membranes and aqueous compartments of the polymersomes. The polymersomes demonstrate a clear photo-responsive characteristic. Exposure to light irradiation at 365 nm can trigger a photocleavage reaction of o-nitrobenzyl groups, which results in dissociation of the polymersomes with simultaneous co-release of hydrophilic and hydrophobic cargoes on demand. Therefore, these polymersomes have great potential as a smart drug delivery nanocarrier for controllable loading and releasing of hydrophilic and hydrophobic drug molecules. Moreover, taking advantage of the conditional releasing of hydrophilic and hydrophobic drugs, the drug delivery system has potential use in medical applications such as cancer therapy.


2013 ◽  
Vol 1 (12) ◽  
pp. 1282 ◽  
Author(s):  
Lan Jiang ◽  
Ze-ming Gao ◽  
Lin Ye ◽  
Ai-ying Zhang ◽  
Zeng-guo Feng

2015 ◽  
Vol 3 (12) ◽  
pp. 2472-2486 ◽  
Author(s):  
Yuning Zhang ◽  
Pontus Lundberg ◽  
Maren Diether ◽  
Christian Porsch ◽  
Caroline Janson ◽  
...  

Histamine functionalized block copolymers were prepared with different ratios of histamine and octyl or benzyl groups using UV-initiated thiol-ene click chemistry.


2016 ◽  
Vol 47 (3) ◽  
pp. 263-273 ◽  
Author(s):  
Elham Khodaverdi ◽  
Melika Javan ◽  
Sayyed A. Sajadi Tabassi ◽  
Bahman Khameneh ◽  
Hossein Kamali ◽  
...  

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
AR Bilia ◽  
G Capecchi ◽  
MC Salvatici ◽  
B Isacchi ◽  
MC Bergonzi

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